Endocrine Abstracts

Background: Pheochromocytoma/Paraganglioma (PPGL) are rare neuroendocrine tumors that expresses somatostatin receptors (SSTR) and can be treated with radiolabeled somatostatin analogues such as Lu-177-DOTATATE. Ga-68-DOTATATE PET scans show the distribution and density of SSTR+ tumors, and F-18-FDG PET scans show hypermetabolism in lesions. Total uptake volumes (TUV) for each respective scan can be obtained consistently and semi-automatically using standardized workflow in ima...

Objective: Our institution (University Hospital “L. Vanvitelli“ - Naples, Italy) is a high-volume (HV) center in Naples metropolitan area and many patients are referred there to repeat thyroid fine-needle aspiration cytology (FNAC) after initial FNAC performed in low-volume institutions (LV). The aims of the study were to 1) to examine the inter-observer agreement between HV and LV institutions according to the Italian thyroid cytology system, and 2) explore how the ...

Aim: Re-Analysing (study starting in 2007) the effect of injectable testosterone undecanoat depot (TUD) in hypogonadic patients.Material-method: A. Patients: at onset 278 men with hypogonadism (median: 61 y).B. Distribution: by decade (starting with 20y); no =6, 17, 25, 70, 86, 55, 18, 1.C. TUD (NebidoR-Bayer) 1000 mg injected one/3 months i.m.D. Prostate volume (PV) apprecia...

AimRe-Analysing (starting 2007) the effect of injectable testosterone undecanoat depot (TUD) in hypogonadic patients.Material-methodA. Patients: at onset 333 men with hypogonadism (median: 62 y).B. Distribution: by decade (starting with 20y->90y); no = 6, 18, 35, 80, 104, 67, 21, 2.C. TUD (Neb...

Although MRI remains the investigation of choice for pituitary imaging, it does not provide information about ‘functionality’ of lesions (e.g. residual adenoma vs post-surgical scar tissue) and cannot reliably identify all microadenomas.We hypothesised that i) imaging with the PET ligand 11C-methionine, which is taken up at sites of peptide/protein synthesis, would permit more reliable identification of functioning pituitary adenoma ...

Aim: Re-analyzing (study starting in 2007) the effect of injectable testosterone undecanoat depot (TUD) in hypogonadic patients.Materials and Methods: A. Patients: at onset 231 men with hypogonadism (median: 62 y). B. Distribution: by decade (starting with 20y); no =4, 14, 24, 61, 63, 49, 17, 1. C. TUD (NebidoR-Bayer) 1000 mg injected one/3 months i.m. D. Prostate volume (PV) appreciated by per-abdominal ultrasound: 3.5–5 MHz probe, ellip...

Background: Metformin is currently the first drug of choice for treatment of type 2 diabetes (T2D). Metformin is known to reduce lipid levels through activation of AMP activated protein kinase-alpha (AMPKα). Metformin induces deficiency of vitamin B12 (B12) in patients with T2D. In humans, studies have shown that low B12 is associated with dyslipidemia (higher triglycerides and low HDL). Therefore, we investigated whether B12 deficiency m...

Background: Vitamin B12 (B12) is an essential micronutrient required for optimal hematopoietic, neurologic and other several metabolic reactions. Longitudinal studies and animal models showed that low maternal vitamin B12 deficiency is associated with the maternal obesity, development of insulin resistance and metabolic syndrome phenotype. Although the mechanisms underpinning metabolic disorders remain poorly defined, it has become increasingly cle...

Background: Metformin is currently the first drug of choice for treatment of type 2 diabetes (T2D). Metformin is known to reduce lipid levels through activation of AMP activated protein kinase-alpha (AMPKα). Metformin induces deficiency of vitamin B12 (B12) in patients with T2D. In humans, studies have shown that low B12 is associated with dyslipidemia (higher triglycerides and low HDL). Therefore, we investigated whether B12 deficiency m...

Background: Vitamin B12 (B12) is an essential micronutrient required for optimal hematopoietic, neurologic and other several metabolic reactions. Longitudinal studies and animal models showed that low maternal vitamin B12 deficiency is associated with the maternal obesity, development of insulin resistance and metabolic syndrome phenotype. Although the mechanisms underpinning metabolic disorders remain poorly defined, it has become increasingly cle...